HIV Post-exposure prophylaxis (PEP/PEPSE) supporting guidelines
Warning
What's new / Latest updates
- Benefits of PEP outweigh risks when overall risk of acquiring the infection is >1/1000
- Risk represented by the source patient is now related to risk of 'detectable' HIV
- Window within which PEP should be administered post exposure has increased from 2hrs to 24hrs
- Guidance is that PEP should not be offered simply because of patient anxiety over possible exposure but on more objective evaluation of the risk. (Linked with this it should be noted the 'All clear' can potentially be given a month earlier if a patient hasn't been given PEP)
- Where PEP not recommended for NHS staff and students Occ Health provide follow up. For other patient GP manages follow up.
- Updated Hep B immunisation schedule updated to match 'The Green Book'. This includes that Hep B vaccine can be given up to 1 week post exposure (although ideally within 24hrs)
- Starter pack may become 7 days (rather than 5 days)
- Indication that Raltegravir dosing may be changing to 2 x 600mg daily
- These drugs do not affect hormonal contraception
- Adjusted advice on breast feeding