For extensive, severe, or bullous impetigo, use oral antibiotics. 

Reserve topical antibiotics for very localised lesions to reduce the risk of resistance where use of Emulsiderm® will not suffice.

Reserve mupirocin for MRSA.

For glossary of terms see Glossary

Drug details

For localised lesions

Fusidic acid 2% ointment. Apply three times daily

5 days to maximum of 10 days

MRSA only:

Mupirocin 2% cream. Apply three times daily

5 days

Extensive, severe or bullous impetigo

Flucloxacillin 500mg four times daily

7 days

In penicillin allergy or if MRSA known or suspected

Doxycycline 100mg twice daily

7 days

Last reviewed: 23 May 2019

Next review: 23 May 2022

Author(s): Antimicrobial Management Team

Approved By: TAM Subgroup of ADTC

Reviewer Name(s): Area Antimicrobial Pharmacist

Document Id: AMT168