Treatment of influenza, including severe immunosuppression
Oseltamivir 75mg twice daily
If resistance to oseltamivir
Zanamivir (inhaled) 10mg twice daily
Prophylaxis of influenza
Oseltamivir 75mg once daily
Prophylaxis of influenza if resistance to oseltamivir
Zanamivir (inhaled) 10mg once daily
Severely immunosuppressed patients should also get oseltamivir first line. Zanamivir is only used if the dominant circulating strain is likely to be oseltamivir resistant.
See the full document for dosing in renal impairment and guidelines for using IV zanamivir.
Annual vaccination is essential for all those at risk of influenza. See Public Health Scotland recommendations for Treatment and Prophylaxis of Influenza. For otherwise healthy adults, antivirals are NOT recommended.
Treat ‘at risk’ patients, only when influenza is circulating in the community and ideally within 48 hours of onset, or in a care home where influenza is likely.
Intravenous zanamivir should only be used if the patient is unable to adequately absorb oral oseltamivir or use inhaled zanamivir. See manufacturer's information for dosing in adults, children aged 6 years and over and in renal impairment.
For glossary of terms see Glossary