NTproBNP less than 400 ng/L (Below cut-off for ECHO referral as per SIGN guideline)
- In an untreated patient heart failure is unlikely.
- Note that obesity, diuretics, ACE inhibitors, Beta-blockers, and ARBs may reduce levels of NTproBNP leading to falsely low levels.
- If clinical suspicion is high consider further investigation.
NTproBNP greater than or equal to 400 ng/L (Raised Levels)
- Results may be in keeping with heart failure. Refer for heart failure ECHO.
- However may be elevated from causes other than heart failure including: left ventricular hypertrophy, ischaemia, tachycardia, right ventricular overload, hypoxaemia (including pulmonary embolism), reduced eGFR (less than 60 mL/min), COPD, diabetes, aged over 70 years), liver cirrhosis.