Nocturnal enuresis

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DESMOPRESSIN

Important: Therapy notes

  • Refer to BNF for cautions.

Important: Formulation and dosage details

Formulation:

Tablets 200 micrograms

Dosage:

Primary nocturnal enuresis (with normal urine concentrating ability), adult (under 65 years) and child over 5 years.
Tablets: 200 micrograms at bedtime, only increased to 400 micrograms if lower dose ineffective.

Important: Formulation and dosage details

Formulation:

Oral lyophilisates (DesmoMelt®) 120 micrograms, 240 micrograms

Dosage:

Primary nocturnal enuresis (with normal urine concentrating ability), adult (under 65 years) and child over 5 years.
Oral lyophilisates: sublingually 120 micrograms at bedtime, only increased to 240 micrograms if lower dose ineffective. Withdraw for at least 1 week for reassessment after 3 months.

Important: Formulation and dosage details

Formulation:

Oral lyophilisates (Noqdirna®) 25 micrograms, 50 micrograms (specialist recommendation)

Dosage:

Noqdirna® to be initiated only on the recommendation of a urology consultant.  Indicated for patients over 65 years of age with difficult-to-treat nocturnal polyuria who have been referred to urology.

  • U+Es for hyponatraemia should be carried out at initiation, 1 week and 1 month
  • Follow up every 3 months in primary care
    • Include assessment of efficacy; specifically reduced number of nocturnal voids
    • And, if clinically indicated, U+E's to check serum sodium
  • Treatment should be discontinued if there is no reduction in the number of nocturnal voids or where serum sodium falls below 135mmol/L.