Specific drugs

The following are the treatments for poisoning used in NHS Highland; stock in individual hospitals is held in agreement with Accident and Emergency consultant staff. Use will be in accordance with national guidance (www.toxbase.org) or in consultation with staff from the National Poisons Information Service (tel: 0344 892 0111). 

ACETYLCYSTEINE

Important: Therapy notes

MHRA advice: Intravenous N-acetylcysteine (NAC) for paracetamol overdose: reminder of authorised dose regimen; possible need for continued treatment with NAC (January 2017) (www.gov.uk).

Important: Formulation

Injection 2 grams/10mL (specialist use only)

ATROPINE

Important: Therapy notes

Important: Formulation

Injection 600 micrograms/mL (specialist use only)

Important: Formulation

Pre-filled syringe 600 micrograms/mL (specialist use only)

BOTULISM ANTITOXIN

Important: Therapy notes

Important: Formulation

Injection [unlicensed] (specialist use only)

CALCIUM CHLORIDE

Important: Therapy notes

Important: Formulation

Injection 10mmol/10mL (specialist use only)

CALCIUM GLUCONATE

Important: Therapy notes

MHRA advice: Calcium gluconate injection in small-volume glass containers: new contraindications due to aluminium exposure risk (December 2014) (www.gov.uk).

Important: Formulation

Gel 2∙5% [unlicensed] (specialist use only)

Important: Formulation

Injection 10% (10mL) (specialist use only)

CLINOLEIC

Important: Therapy notes

Important: Formulation

Infusion 20% 500mL (specialist use only)

CYPROHEPTADINE HYDROCHLORIDE

Important: Therapy notes

Important: Formulation

Tablets 4mg (specialist use only)

DANTROLENE SODIUM

Important: Therapy notes

MHRA advice: Intravenous dantrolene: risk of undissolved crystals (December 2014) (www.gov.uk).

Important: Formulation

Injection 20mg (specialist use only)

DESFERRIOXAMINE

Important: Therapy notes

Important: Formulation

Injection 500mg (specialist use only)

DIGOXIN-SPECIFIC ANTIBODY FRAGMENTS (F( ab))

Important: Therapy notes

Important: Formulation

Powder for reconstitution for intravenous infusion (DigiFab®)  40mg/vial (specialist use only)

DISODIUM FOLINATE

Important: Therapy notes

The disodium salt of folinic acid is stocked in Raigmore hospital in preference to the calcium salt.

Important: Formulation

Injection 400mg/8mL (specialist use only)

EUROPEAN VIPER VENOM ANTISERUM

Important: Therapy notes

Important: Formulation

Injection (snake venom antiserum)  [unlicensed] (specialist use only)

FLUMAZENIL

Important: Therapy notes

Important: Formulation

Injection 500 micrograms/5mL (specialist use only)

FOMEPIZOLE

Important: Therapy notes

Important: Formulation

Injection 1 gram/mL [unlicensed] (specialist use only)

GLUCAGON

Important: Therapy notes

Important: Formulation

Injection (GlucaGen® HypoKit) 1mg (specialist use only)

GLYCERYL TRINITRATE

Important: Therapy notes

Important: Formulation

Injection 5mg/5mL, 50mg/50mL (specialist use only)

HYDROXOCOBALAMIN

Important: Therapy notes

Important: Formulation

Injection (Cyanokit®) 5 grams (specialist use only)

IDARUCIZUMAB

Important: Therapy notes

Important: Formulation

Solution for injection/infusion (Praxbind®) 2·5g/50mL (specialist use only)

MACROGOL 3350 WITH POTASSIUM CHLORIDE, SODIUM BICARBONATE AND SODIUM CHLORIDE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Oral powder sachets 110 grams/sachet (VistaPrep®(hospital use only)

Dosage:

Whole bowel irrigation (by means of a bowel cleansing preparation) has been used in poisoning with certain modified-release or enteric-coated formulations, in severe poisoning with iron and lithium salts, and if illicit drugs are carried in the gastro-intestinal tract (‘body-packing’). However, it is not clear that the procedure improves outcome and advice should be sought from the National Poisons Information Service.
See BNF - Poisoning, emergency treatment

MESNA

Important: Therapy notes

Important: Formulation

Injection 1 gram/10mL (specialist use only)

METHYLTHIONINIUM CHLORIDE (METHYLENE BLUE)

Important: Therapy notes

MHRA advice: Methylthioninium chloride (methylene blue): update on central nervous system (CNS) toxicity (December 2014) (www.gov.uk).

Important: Formulation

Injection 50mg/10mL (specialist use only)

NALOXONE

Important: Therapy notes


Risk minimisation materials

Important: Formulation

Injection 400 micrograms/mL (specialist use only)

OCTREOTIDE

Important: Therapy notes

Important: Formulation

Injection 50 micrograms/mL (specialist use only)

PHENTOLAMINE

Important: Therapy notes

Important: Formulation

Injection 10mg/mL [unlicensed] (specialist use only)

PHYTOMENADIONE

Important: Therapy notes

Important: Formulation

Injection 10mg/mL (specialist use only)

PRALIDOXIME

Important: Therapy notes

Stock held in Raigmore Pharmacy Store.

Important: Formulation

Injection 1 gram (specialist use only)

PROCYCLIDINE

Important: Therapy notes

Important: Formulation

Injection 10mg/2mL (specialist use only)

PROTAMINE SULFATE

Important: Therapy notes

Important: Formulation

Injection 50mg/5mL (specialist use only)

SODIUM BICARBONATE

Important: Therapy notes

Important: Formulation

Infusion 1·26%, 8·4% (specialist use only)

SODIUM NITRITE

Important: Therapy notes

NHS Improvement Patient Safety Alert: Risk of death from unintended administration of sodium nitrite (August 2020)

 

Important: Formulation

Solution for injection 30mg/ml

SODIUM THIOSULFATE

Important: Therapy notes

Important: Formulation

Injection 25% (250mg/mL) (specialist use only)

Last reviewed: 15 May 2020