Vuvlvo-vaginal Candidiasis

All topical and oral azoles give 75% cure.

First episode can be treated empirically. For recurrent or persistent symptoms, perform examination and high vaginal swab.

Give general skin care and washing advice - information leaflet available here:

Drug details

Uncomplicated symptomatic vaginal candidiasis

Clotrimazole 500mg pessary or 5g of 10% vaginal cream

As a single dose

OR Fluconazole 150mg

As a single dose

In pregnancy avoid oral azole, eg fluconazole

Clotrimazole 500mg pessary at night

Up to 7 nights

Severe infection

Clotrimazole pessary 500mg on days 1 and 4


Fluconazole 150mg tablet on days 1 and 4

Recurrent infection

Induction - Fluconazole 150mg tablet on days 1,4 and 7. Maintenance for 6 months: Fluconazole 150mg tablet weekly

Alternative Induction - Clotrimazole 200mg pessary daily for 7-14 days. Maintenance for 6 months Clotrimazole pessary 500mg weekly.

Last reviewed: 27 April 2022

Next review: 27 April 2025

Author(s): Antimicrobial Management Team

Approved By: TAM Subgroup of ADTC

Reviewer Name(s): Area Antimicrobial Pharmacist

Document Id: AMT130