Mucolytics

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Consider carbocisteine in patients with COPD and chronic cough productive of sputum. Continue if there is symptomatic improvement. If there is no benefit after a 4-week trial, stop therapy. Nebulised sodium chloride 0•9% solution has no place as a mucolytic in either COPD or asthma.

CARBOCISTEINE

Therapy notes

Formulation and dosage details

Formulation:

Capsules 375mg

Dosage:

750mg 3 times daily initially, then 375mg 4 times daily as condition improves.

Formulation and dosage details

Formulation:

Oral liquid 250mg/5mL

Dosage:

750mg 3 times daily initially, then 375mg 4 times daily as condition improves.

DORNASE ALFA

Therapy notes

Formulation

Nebuliser solution 2•5mg (2500 units)/2•5mL (specialist initiation)