Antifungal drugs for specialist use only

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Use only in accordance with protocols or on advice of Microbiology, Infectious Diseases or appropriate Consultant Specialist.

AMPHOTERICIN B

Important: Therapy notes

MHRA advice: Liposomal and lipid-complex formulations: name change to reduce medication errors (July 2020) (www.gov.uk).
MHRA advice: Parenteral amphotericin B: reminder of risk of potentially fatal adverse reaction if formulations confused (July 2018) (www.gov.uk).

Important: Formulation

Infusion 50mg (Fungizone®) (s)

Important: Formulation

Powder for dispersion for infusion 50mg (AmBisome Liposomal®) (s)

ANIDULAFUNGIN

Important: Therapy notes

Important: Formulation

Infusion 100mg (s)

CASPOFUNGIN

Important: Therapy notes

Important: Formulation

Infusion 50mg, 70mg (s)

FLUCYTOSINE

Important: Therapy notes

MHRA alert: Flucytosine (Ancotil): new contraindication in patients with DPD deficiency (October 2020) (www.gov.uk).

Important: Formulation

Infusion 2·5 grams/250mL

POSACONAZOLE

Important: Therapy notes

MHRA advice: Posaconazole (Noxafil): tablets and oral suspension are not directly interchangeable (September 2016) (www.gov.uk).

  • Use tablets in preference to the oral suspension. 
  • Due to differences in the dosing of each formulation the tablets and oral suspension are not interchangeable.

Important: Formulation

Tablets 100mg (hospital use only)

Important: Formulation

Oral suspension 200mg/5mL (hospital use only)

VORICONAZOLE

Important: Therapy notes

MHRA advice: Voriconazole: reminder of risk of liver toxicity, phototoxicity, and squamous cell carcinoma (December 2014) (www.gov.uk).

Risk minimisation materials

Important: Formulation

Tablets 50mg, 200mg (Hospital use only)

Important: Formulation

Oral suspension 200mg/5mL (Hospital use only)

Important: Formulation

Intravenous infusion 200mg (Hosptial use only)