Acute Coronary Syndrome (ACS)
exp date isn't null, but text field is
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Tenecteplase (TNK) dosing regimen |
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Age < 75 yrs |
Age ≥ 75 yrs |
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Weight (kg) |
TNK (units) |
TNK (mg) |
Vol (ml) |
TNK (units) |
TNK (mg) |
Vol (ml) |
|
< 60 |
6,000 |
30 |
6 |
3,000 |
15 |
3 |
|
60 - < 70 |
7,000 |
35 |
7 |
3,500 |
17.5 |
3.5 |
|
70 - < 80 |
8,000 |
40 |
8 |
4,000 |
20 |
4 |
|
80 - < 90 |
9,000 |
45 |
9 |
4,500 |
22.5 |
4.5 |
|
≥ 90 |
10,000 |
50 |
10 |
5,000 |
25 |
5 |
Unfractionated heparin i.v. infusion (only if eGFR < 15)
Following i.v. UFH bolus, start i.v. UFH infusion of 12 units per kg, up to a maximum of 1,000 units/h for 24 to 48 hours. Target aPTT: 50-70 s, or 1.5 to 2.0 times control at 3, 6, 12 and 24 h
For further more detailed information please see Europeon Society of Cardiology (ESC) guidance:
Management of Acute Myocardial Infarction in patients presenting with ST-segment elevation
| Abbreviation | Meaning |
| GTN | Glyceryl trinitrate |
| ECG | Electrocardiogram |
| CCU | Coronary care unit |
| STEMI | ST-Elevation Myocardial Infarction |
| AV | Atrioventricular block |
| SBP | Systolic blood pressure |
| DBP | Diastolic blood pressure |
| LBBB | Left bundle branch block |
| eGFR | Estimated glomerular filtration rate |
| DOAC | Direct oral anticoagulants |
| UFH | Unfractionated heparin |
| aPTT | Activated partial thromboplastin time |
| PCI | Percutaneous Coronary Intervention |
Last reviewed: 30 August 2021
Next review: 30 August 2024
Author(s): Department of Cardiology
Version: 8
Approved By: TAM Subgroup of ADTC
Reviewer Name(s): Consultant Cardiologist - Jonathan Watt
Document Id: TAM135